Edges of the Mind

Treating Schizophrenia as Psychiatry Evolves

A powerful memoir from one of America's leading psychiatrists, chronicling four decades on the front lines of serious mental illness and the remarkable transformation of psychiatry.

Coming Fall 2026


“This book is a powerhouse of drama and science and compassion told through the  eyes of a doctor on the frontlines of our nation’s struggle with serious mental illness.”

- Tim Shriver

Chairman of Special Olympics and Founder of UNITE

Why This Book Matters

THE PATIENTS

Series of individuals and families living with schizophrenia.

THE SCIENCE

The breakthroughs that were transformed psychiatry from neuroscience.

THE FUTURE

Why mental health care still has a long way to go.

What You'll Discover

  • Inside the realities of schizophrenia

  • The evolution of psychiatric medicine

  • Behind-the-scenes stories from Yale and NIMH

  • Breakthrough discoveries in neuroscience

  • The human side of serious mental illness

  • Lessons for families, clinicians, and policymakers

Who Should Read This Book

MENTAL HEALTH PROFESSIONALS

Psychiatrists, psychologists, counselors, social workers, and technicians.

FAMILIES

Loved ones affected by serious mental illness seeking understanding and hope.

STUDENTS

Medicine, neuroscience, psychology. public health, and related fields.

GENERAL READERS

Anyone interested in medicine, science, and stories of resilience and discovery.

Why I Wrote Edges of the Mind

Each time I sat with a patient living with schizophrenia and tried to understand the often-painful reality of their illness, I felt a strong need to write about what I had witnessed. I did not want to write another scientific paper. I wanted to speak more directly to the people who know this illness in deeply personal ways—patients, families, and clinicians like me. After a full professional life spent caring for and learning from these patients, I have turned to the stories themselves: their stories, their families’ stories, and, inevitably, my own.

Writing has long been important to me, and I believe it can offer a different kind of understanding—one rooted not only in science, but also in memory, compassion, and human connection.

Praise for Edges of the Mind

- Tim Shriver

- Chairman of Special Olympics and Founder of UNITE

“This book is a powerhouse of drama and science and compassion told through the  eyes of a doctor on the frontlines of our nation’s struggle with serious mental illness.”


- Michael Gottlieb, MD

Physician who was the first to identify AIDS

David Pickar, M.D. dedicated his life in medicine to treating and studying patients  with schizophrenia, the most disabling and misunderstood of the psychiatric  illnesses. His research at Yale and the National Institute of Mental Health (NIMH )  has been foundational to our understanding of the etiology and treatment of this  enigmatic brain disease. Edges of the Mind is an engaging memoir as well as a  history of the remarkable progress in brain psychopharmacology that evolved over  the course of his career.


- Laurie Flynn

Former Executive Director, National Alliance on Mental Illness (NAMI)

The engrossing story of a distinguished researcher’s journey across the shifting  landscape of psychiatry in the latter half of the twentieth century and into the  millennium, Dr. Pickar illustrates the history of modern psychiatry with compelling  patient stories that give shape to the lived experience of serious mental illness. His  clinical research, advocacy, and public speaking have given hope to thousands of  NAMI families across the nation.